Major depression, anxiety, and OCD require antidepressants. Many worry about their adverse effects, especially weight gain. A recent Annals of Internal Medicine study examined weight fluctuations with several antidepressants.
The study examined 183,118 new antidepressant users. Researchers found that bupropion (Wellbutrin) caused the least weight gain. Escitalopram, paroxetine, and duloxetine caused the largest weight increase.
After starting the medicine, weight was measured at baseline, 6 months, 1 year, and 2 years. Bupropion users had a 15% lower risk of acquiring at least 5% of their baseline weight than sertraline (Zoloft) users. Escitalopram, duloxetine, and paroxetine users had a 10-15% increased chance of severe weight gain.
Despite these findings, the study contains drug adherence and weight data gaps. At 6 months, 28–41% of individuals took their medicine, declining to 4–5% at 2 years. The study cannot prove causation between antidepressants and weight changes because it was observational.
However, this study emphasizes the need for patient-side effect discussion. Dr. Erich J. Conrad of LSU Health New Orleans said weight gain can help prescribers create more effective and tailored antidepressant treatments.
In conclusion, antidepressants are essential for mental health, but doctors must balance the risks, such as weight gain. This method improves drug adherence and patient health.
